CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection

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CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection

OBJECTIVE HIV type 2 (HIV-2) represents an attenuated form of HIV, in which many infected individuals remain 'aviremic' without antiretroviral therapy. However, aviremic HIV-2 disease progression exists, and in the current study, we therefore aimed to examine if specific pathological characteristics of CD4 T cells are linked to such outcome. DESIGN HIV-seronegative (n = 25), HIV type 1 (HIV-1...

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ژورنال

عنوان ژورنال: AIDS

سال: 2016

ISSN: 0269-9370

DOI: 10.1097/qad.0000000000001223